WEST LAFAYETTE, Ind. — D.J. Knox rushed for 128 yards and three touchdowns, David Blough threw for three more scores and Purdue shook up the College Football Playoff chase with a 49-20 blowout of No. 2 Ohio State on Saturday.

The Boilermakers (4-3, 3-1 Big Ten) won their fourth straight overall, their second in a row over a ranked team and pulled off their biggest upset since taking down then-No. 2 Ohio State 28-23 on Oct. 6, 1984. Purdue also set a school record for points scored against the Buckeyes, besting the previous mark of 41 in 1967.

Mistake-prone Ohio State (7-1, 4-1) had its 12-game winning streak snapped, fell out of the Big Ten East lead behind rival Michigan and now must fight away its way back into playoff position.

Blough outplayed Heisman Trophy candidate Dwayne Haskins Jr. on a night the Buckeyes didn’t reach the end zone until early in the fourth quarter.

Purdue 49, No. 2 Ohio St. 20

Ohio St. 0 3 3 14—20

Purdue 7 7 7 28—49

First Quarter

PUR_Zico 13 pass from Blough (Sp.Evans kick), 1:10

Second Quarter

OSU_FG Haubeil 24, 14:14

PUR_Moore 9 pass from Blough (Sp.Evans kick), :27

Third Quarter

OSU_FG Haubeil 23, 12:25

PUR_D..Knox 1 run (Sp.Evans kick), 8:36

Fourth Quarter

PUR_D..Knox 42 run (Sp.Evans kick), 11:39

OSU_Dixon 32 pass from Haskins (Haubeil kick), 9:36

PUR_D..Knox 40 run (Sp.Evans kick), 6:46

OSU_McLaurin 34 pass from Haskins (Haubeil kick), 4:40

PUR_Moore 43 pass from Blough (Sp.Evans kick), 3:37

PUR_Bailey 41 interception return (Sp.Evans kick), 2:08

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OSU PUR

First downs 31 24

Rushes-yards 25-76 29-161

Passing 470 378

Comp-Att-Int 49-73-1 25-43-0

Return Yards 114 58

Punts-Avg. 5-36.8 6-37.33

Fumbles-Lost 0-0 1-0

Penalties-Yards 10-86 7-95

Time of Possession 31:17 28:43

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INDIVIDUAL STATISTICS

RUSHING_Ohio St., Weber 9-45, Dobbins 11-24, Haskins 5-7. Purdue, D..Knox 16-128, Moore 2-24, Mar.Jones 5-12, Schopper 1-4, Blough 5-(minus 7).

PASSING_Ohio St., Haskins 49-73-1-470. Purdue, Blough 25-43-0-378.

RECEIVING_Ohio St., K.Hill 9-105, Campbell 9-43, Victor 5-67, McLaurin 5-66, Weber 5-22, Dixon 4-58, Dobbins 4-34, Farrell 4-24, Saunders 2-17, Mack 1-24, Berry 1-10. Purdue, Moore 12-170, Sparks 3-43, Hopkins 3-37, Zico 2-50, Herdman 2-36, Anthrop 2-16, D..Knox 1-26.

MISSED FIELD GOALS_Ohio St., Haubeil 33.